When her father unexpectedly passes away, young Ella finds herself at the mercy of her cruel stepmother and her daughters. Never one to give up hope, Ella's fortunes begin to change after meeting a dashing stranger.

Susan Murphy gets turned into a giant monster on her wedding day when a meteorite from outer space hits her. She is taken to a secret government compound where she meets a ragtag group of monsters also rounded up over the years. As a last resort, under the guidance of General W.R. Monger, on a desperate order from The President, the motley group of Monsters are called into action to combat the aliens and save the world from imminent destruction.

After moving to the country to be near their ailing mother, two young sisters are befriended by a variety of mysterious creatures.